Studies on Pyrimidine Derivatives. VI

Receptor Tyrosine Kinase Inhibitory Activities and Molecular Docking Studies of Some Pyrrolo[2,3-d]pyrimidine Derivatives

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

Studies on Digitalis VI

T IS undisputed that the administration of digitalis to patients with many forms of congestive heart failure results in an improvement in both the clinical state and in the abnormal circulatory dynamics that are characteristic of heart failure.'-6 The effects of digitalis in subjects without heart failure are less well defined. Although some glycosides augment the contractile force of nonfailin...

Molecular docking studies on mycobacterial tuberculosis-6-oxopurine phosphoribosyltransferase EMRB with pyrimidine derivatives

Pyrimidine derivatives are associated with broad spectrum of biological activities including anti-microbial, anticancer, anti-inflammatory etc. This prompted us to use compounds containing pyrimidine moiety and to evaluate for anti microbial activity. The present study is an in silico approach that aims at finding out the potency of pyrimidine derivatives against multidrug resistant protein of ...

Studies on nicotinamide derivatives.

Free radical scavenging properties of pyrimidine derivatives

Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive generation of free radicals and reduced level of antioxidants, but at low concentrations, these radicals help to perform normal physiological functions of the body. Scientific evidence sugges...